Assessment of homeopathic medicine Aconitum napellus in the treatment of anxiety in an animal model

  • Gabriele Baptista Haine
  • Samarah Hamidi El Ghandour
  • Sâmia Ahmad El Ghandour
  • Andersom Ricardo Fréz
Keywords: Anxiety, homeopathy, Aconitum napellus, animal model, rats


Background: Aconitum napellus is a classic resource of complementary medicine for the treatment of patients exhibiting neurological symptoms of anxiety. Aim: To assess the action of homeopathic medicine Acon in the treatment of generalized anxiety in an experimental model using rats. Methods: 48 adult (two to three months old) male Wistar rats (Rattus rattus) were randomly divided in six groups (n= 8/treatment) and given the following treatments by gastric tube along 10 days: 1) control (diazepam 1 mg/kg/day); 2) negative control (0.15 mL saline solution/day); 3) ACH6 (0.15 mL Acon (6cH/day); 4) ACH12 (0.15 mL Acon 12cH/day); 5) ACH30 (0.15 mL Acon 30cH/day); and 6) ALC30 (0.15 mL 30% cereal alcohol/day). Behavioral effects were blindly and randomly assessed in elevated plus maze (EPM) and open field test. Results: Acon in dilutions 12cH and 30cH exhibited possible anxiolytic effects on the central nervous system (CNS) since they increased the number of entries in the EPM open arms (12cH and 30cH) and the permanence time in the EPM open arms (30cH only). In the open field test the homeopathic preparations did not show effects on the locomotor system of rats. Conclusion: Dilutions 12cH and 30cH of Acon exhibited anxiolytic effects on the CNS in an animal experimental model.

Author Biographies

Gabriele Baptista Haine
Farmacéutica pela Faculdade Anglo-Americano (FAA).
Samarah Hamidi El Ghandour
Farmacéutica pela Faculdade Anglo-Americano (FAA).
Sâmia Ahmad El Ghandour
Farmacéutica pela Faculdade Anglo-Americano (FAA).
Andersom Ricardo Fréz
Fisioterapeuta pela Universidade Estadual do Oeste do Paraná (Unioeste). Mestre em Saúde, Interdisciplinaridade e Reabilitação pela Universidade Estadual de Campinas (Unicamp). Doutorando em Ciéncias Médicas pela Universidade de São Paulo (USP).
Pharmaceutical Research