Evaluation of the effect of different concentrations of Arsenicum album 6cH on intoxicated rats

Authors

  • Olney Leite Fontes
  • Fátima Cristiane Lopes Goularte Farhat
  • Amarilys Toledo Cesar
  • Marilisa Guimarães Lara
  • Maria Imaculada Lima Montebelo
  • Cíntia Maria Bertaglia Luizetto
  • Marco Vinícius Chaud

DOI:

https://doi.org/10.51910/ijhdr.v8i28.349

Keywords:

high dilution - dosage in high dilutions - Arsenicum album.

Abstract

Aims: Homeopaths diverge on the concept of dose, i.e. the amount of drug that a patient must take to alter his or her state of disease. In order to stimulate reflections on this concept, this study sought to evaluate in vivo the effect of different concentrations of Arsenicum album 6cH prepared according to homeopathic pharmacotechnics. Methods: male Wistar rats were intoxicated with arsenic and then treated with Arsenicum album 6cH and Arsenicum album 6cH diluted at 1%, administered orally. The amount of arsenic retained in the animals’ organism and that eliminated by urine were measured through atomic absorption spectroscopy. Samples of urine were collected before and after intoxication and during treatment. The positive control group (intoxicated animals) and the negative control group (non-intoxicated animals) received only the vehicle used in the preparation of the medicine. Results: Groups treated with Arsenicum album 6cH and Arsenicum album 6cH diluted at 1% eliminated significant amounts of arsenic when compared to the control groups. The group treated with Arsenicum album 6cH eliminated significantly higher amounts of arsenic than the group treated with the diluted medicine at 1%. Conclusion: results suggest that Arsenicum album 6cH should not be diluted as not to compromise its effectiveness in the treatment of rats intoxicated with arsenic.

Author Biographies

Olney Leite Fontes

Methodist University of Piracicaba, Pharmaceutics Course, Faculty of Health Sciences

Fátima Cristiane Lopes Goularte Farhat

Methodist University of Piracicaba, Pharmaceutics Course, Faculty of Health Sciences

Amarilys Toledo Cesar

Medical School of Jundiaí, Specialization Course in Homeopathy

Marilisa Guimarães Lara

University of São Paulo, Faculty of Pharmaceutical Sciences of Ribeirão Preto

Maria Imaculada Lima Montebelo

Pharmaceutics Course, Faculty of Health Sciences, Methodist University of Piracicaba

Cíntia Maria Bertaglia Luizetto

Methodist University of Piracicaba, Pharmaceutics Course, Faculty of Health Sciences

Marco Vinícius Chaud

Methodist University of Piracicaba, Pharmaceutics Course, Faculty of Health Sciences

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Published

2021-12-28

How to Cite

Fontes, O. L., Farhat, F. C. L. G., Cesar, A. T., Lara, M. G., Montebelo, M. I. L., Luizetto, C. M. B., & Chaud, M. V. (2021). Evaluation of the effect of different concentrations of Arsenicum album 6cH on intoxicated rats. International Journal of High Dilution Research - ISSN 1982-6206, 8(28), 119–127. https://doi.org/10.51910/ijhdr.v8i28.349

Issue

Section

Pharmaceutical Research

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