Why is catalase so fast?
Abstractded network of hydrogen-bonded water and H2O2 molecules, stretching out far beyond the enzymesâ€™ active sites, into the cell's internal aqueous medium. As catalases function, they provide coherent oxidative â€˜pulsesâ€™, which rapidly spread throughout the H-bonded network, effectively â€˜unzippingâ€™ H2O2Â molecules as far as they extend from the enzyme. Result/discussion: This 'memory-of-water'-like mechanism predicts catalase H2O2 disproportionation should occur outside the enzyme. An experimental protocol is proposed to test this prediction. If successful, it would suggest a) holistic re-appraisal of the conventional mechanistic framework of enzyme kinetics is required, and b) should encourage more research into understanding the biochemical effects of CAM therapies. Keywords: Holistic biochemistry; catalase enzymes; hydrogen peroxide disproportionation; hydrogen-bonded networks; memory of water.
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