Evaluation of Antihyperglycemic potential of homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in Streptozotocin Induced diabetic Rats.

Authors

Keywords:

Antihyperglycemic, Homeopathy, Mineral, Streptozotocin, Sarcodes

Abstract

INTRODUCTION – Diabetes Mellitus is an emerging endocrine and metabolic disorder which has affected millions of people globally. Homeopathy a science of ultra-molecular doses with a holistic approach is used in treatment of Diabetes Mellitus. Homeopathic medicines are prepared from plant, mineral, sarcodes, nosodes and animal parts. Insulinum, Pancreatinum and Uranium nitricum is used in homeopathy for treatment of Diabetes Mellitus. However no any preclinical studies have been investigated for the anti-diabetic effect and its safety. METHODS – Homeopathic medicines Insulinum, Pancreatinum and Uranium nitricum in 6C (1012) dilution factor were used to examine antihyperglycemic effects in streptozotocin induced diabetic rats. After 28 days treatment bodyweight, Hematology, Biochemistry (serum glucose, urea, creatinine, SGPT, SGOT, ALP, Triglyceride and HDL-cholesterol), Oral Glucose Tolerance Test, HbA1C with histopathology of (Liver, Kidney, Pancreas) was measured. RESULTS – After Streptozotocin induction, the animals have shown significant increase in the fasting blood glucose level (p<0.01) as compared to normal control animals. Treatment with homeopathic medicine Insulinum, Pancreatinum and Uranium nitricum in ‘6C’ potency showed significant decrease in levels of Glucose (p<0.05), OGTT, Total protein (P<0.001), ALP (P<0.05), Cholesterol (P<0.001), SGPT (P<0.001), SGOT (p<0.01), Urea, HbA1C as compared to diabetic animal. CONCLUSIONS – In the present study homeopathic medicine Insulinum, Pancreatinum and Uranium nitricum in ‘6C’ potency exhibits antihyperglycemic effects in streptozotocin induced diabetic rats.

Author Biography

Aditya Dilipkumar Patil, Bharati Vidyapeeth

Post Graduate Scholar in Homeopathic Pharmacy at Bharati vidyapeeth homeopathic medical College and hospital. Pune, Maharashtra, India

Downloads

Published

2020-07-09

Issue

Section

Basic Research (Biology)